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Opioid exercise is because of equally very low affinity binding with the mum or dad compound and better affinity binding of the O-demethylated metabolite M1 to μ-opioid receptors. In animal types, M1 is approximately 6 situations more strong than tramadol in developing analgesia and 200 periods a lot more strong in μ-opioid binding.C. Critique of

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